Sodium phenylacetate sodium benzoate

The products dosage form is injection solution concentrate and is administered via intravenous form. In treatment of metabolic imbalances caused by maple syrup urine disease MSUD peritoneal dialysis and hemofiltration pharmacological treatments for elimination of toxic metabolites can be used in addition to basic dietary modifications.

The dilution and dosage of sodium.

Sodium phenylacetate sodium benzoate. 10 Zeilen Sodium phenylacetate and sodium benzoate injection contains 305 mg of sodium per mL of. Sodium phenylacetate and benzoate injection combination is used to treat hyperammonemia which is a condition where there is too much ammonia in the blood. Ammonia is formed from the breakdown of protein in the body.

If the ammonia cannot be removed by the body high amounts in the blood may cause serious unwanted effects. This medicine works to reduce the amount of ammonia. Sodium phenylacetate has a molecular weight of 15813 and the molecular formula C 8 H 7 NaO 2.

Sodium benzoate has a molecular weight of 14411 and the molecular formula C 7 H 5 NaO 2. Each mL of AMMONUL contains 100 mg of sodium phenylacetate and 100 mg of sodium benzoate and Water for Injection. Each g of sodium phenylacetate provides 63 mEq 145 mg of sodium and each g of sodium benzoate provides 7 mEq 160 mg of sodium.

Each mL of injection concentrate labeled as containing 100 mg each of sodium phenylacetate and sodium benzoate provides 133 mEq 305 mg of sodium. Sodium Phenylacetate And Sodium Benzoate with NDC 13811-705 is a a human prescription drug product labeled by Trigen Laboratories Llc. The generic name of Sodium Phenylacetate And Sodium Benzoate is sodium phenylacetate and sodium benzoate.

The products dosage form is injection solution concentrate and is administered via intravenous form. Ammunol sodium phenylacetatesodium benzoate is an intravenously administered investigational drug used for the treatment of acute hyperammonemia in infants children and adults with urea cycle enzyme deficiencies. Sodium Phenylacetate and Sodium Benzoate Injection 10 per 10 a nitrogen binding agent is a sterile concentrated aqueous solution of sodium phenylacetate and sodium benzoate.

The pH of the solution is between 6 and 8. Sodium phenylacetate is a white to off-white powder. It is soluble in water.

Sodium benzoate is a white to off-white powder that is readily soluble in water. Pharmacokinetics of sodium phenylacetate and sodium benzoate following intravenous administration as both a bolus and continuous infusion to healthy adult volunteers. MacArthur RB Altincatal A Tuchman M Mol Genet Metab 2004 Apr81 Suppl 1S67-73.

Therapy with sodium phenylacetatebenzoate or sodium pheny. In treatment of metabolic imbalances caused by maple syrup urine disease MSUD peritoneal dialysis and hemofiltration pharmacological treatments for elimination of toxic metabolites can be used in addition to basic dietary modifications. Uses of Sodium Phenylacetate and Sodium Benzoate.

It is used to treat urea cycle problems. What do I need to tell my doctor BEFORE I take Sodium Phenylacetate and Sodium Benzoate. If you are allergic to sodium phenylacetate and sodium benzoate.

Any part of sodium phenylacetate and sodium benzoate. Or any other drugs foods or substances. Tell your doctor about.

Urea Cycle Enzyme Deficiency. Indicated as adjunctive therapy for the treatment of acute hyperammonemia and associated. Sodium phenylacetate is conjugated with glutamine to form glutamine phenylacetate and is eliminated in the urine sodium benzoate is conjugated with glycine to form hippuric acid and is eliminated in the urine Arginine becomes essential in infants with an ASL arginosuccinate lysase.

Sodium phenylacetate and sodium benzoate cause metabolite formation providing alternate pathways for the removal of ammonia. One mole of sodium phenylacetate removes two moles of nitrogen. One mole of sodium benzoate removes one mole of nitrogen.

Occurs in liver and kidneys. Sodium phenylacetate conjugates with glutamine forming the active metabolite. 2 DOSAGE AND ADMINISTRATION 21 Recommended Dose - Sodium phenylacetate and sodium benzoate injection must be diluted with sterile 10 Dextrose Injection D10W before administration.

The dilution and dosage of sodium. 3 DOSAGE FORMS AND STRENGTHS.