Ivf double stimulation protocol

Remarkably the Duplex protocol is unexpectadly well tolerated by women and provides twice as many oocytes and embryos as. Some patients may develop only very few eggs and the stimulation will have to be repeated while others may over-react with a risk of a.

After the first oocyte retrieval human menopausal gonadotrophin and letrozole were administrated to stimulate follicle development and oocyte retrieval was carried out a.

Ivf double stimulation protocol. Double stimulation and egg collection the best protocol for poor responders 1 Give indocin indomethacin at the time of the GnRH agonist trigger so as to give you several hours of grace before. 2 Follow the LH daily as the clomid will prevent a sudden surge. As the LH creeps up first before.

This article describes a revised ovarian stimulation protocol DuoStim for fertility preservation in female oncology patients which aims to maximise the number of gametes obtained with subsequent improvement in cumulative birth rate without delaying cancer treatment. Ten patients diagnosed with malignancy between September 2014 and October 2015 were included. The patients were treated.

Double stimulation in the same ovarian cycle DuoStim is a relatively new protocol for patients with poor ovarian reserve undergoing IVF. Unlike traditional IVF protocols where patients undergo a single round of ovarian stimulation with fertility drugs and egg retrieval in one menstrual cycle in the DuoStim protocol patients undergo two rounds of ovarian stimulation and two egg retrievals in the same menstrual cycle. Despite several different approaches variable doses and adjuvant therapies the successful treatment of poor responders in IVF remains a stubborn clinical challenge.

Now a new observational study of a dual stimulation protocol appears to offer a very promising strategy. ESHREs second venture into diagnostic consensus - following the Rotterdam. The protocol of double stimulation during the follicular and luteal phases is presented in Figure 1.

Endometrial preparation and cryopreserved embryo transfer Embryo and endometrium synchronization in cryopreserved embryo transfer cycles in this study was according to the method described earlier Kuang et al 2013. 2016 proposed the double stimulation protocol which they called DuoStim for patients with reduced ovarian reserve taking into account the time as an important factor for all patients but it is crucial for those with have a foreseeable rapid lossdecrease of fertility. This step will be done twice in two different cycles In each cycle.

Luteal phase priming using combined contraceptive pills from day 21 of the previous cycle for one week by Gynera tab. Controlled ovarian hyper-stimulation using antagonist protocol will be used. Stimulation with 225-375 IU of gonadotropins will be started day 2-3 of menses after vaginal ultrasound confirming the absence of.

The double stimulation or DuoStim protocol combines conventional follicular phase stimulation together with luteal phase stimulation so that two oocyte retrieval procedures can be performed. This study is a prospective before after clinical trial to investigate the efficacy of double stimulations during both the follicular and luteal phases in patients with poor ovarian response undergoing IVF and intracytoplasmic sperm injection ICSI cycles. The study protocol is approved by the Ethics Committee Institutional.

There are several options for ovarian stimulation but they all include a series of different medications taken over several daysweeks called a stimulation protocol. There is no one treatment scheme that works for each woman undergoing fertility treatment. Some patients may develop only very few eggs and the stimulation will have to be repeated while others may over-react with a risk of a.

Double stimulation IVF DuoStim DuoStim method is based on double stimulation during the same cycle. The stimulation starts as usually on the second-third day of a cycle. After the egg retrieval in few days second stimulation starts so that the follicles which did not grow enough during the first stimulation phase could mature.

In a pilot study the efficacy of double stimulations during the follicular and luteal phases in women with poor ovarian response was explored defined according to the Bologna criteria. Thirty-eight women began with mild ovarian stimulation. After the first oocyte retrieval human menopausal gonadotrophin and letrozole were administrated to stimulate follicle development and oocyte retrieval was carried out a.

Natural Cycle IVF In 1978 the first successful IVF procedure was performed without the use of drugs. This technique was abandoned due to low success rates in subsequent attempts. Since then technology and laboratory techniques have improved dramatically and the pregnancy rate after transfer of one embryo increased enabling physicians to reintroduce the concept of natural cycle.

A recent Duplex protocol features a dual stimulation with the second stimulation started immediately after the first oocyte retrieval. Remarkably the Duplex protocol is unexpectadly well tolerated by women and provides twice as many oocytes and embryos as. The full protocol developed by IVF Spain consists of two steps.

The first step consists of a one week stay at their Alicante clinic where the patient undergoes controlled ovarian hyper-stimulation. Due to the specific approach this process carries an almost non-existent risk of inducing OHSS in the patient. As mentioned above double stimulation during the follicular and luteal phases in the same menstrual cycle provided more opportunities to retrieve oocytes in poor responders with the resulting embryos having similar development potential.

Double stimulation and subsequent cryopreserved embryo transfer is a promising approach both for patients with POR especially for the cases that repeatedly did not have oocytes retrieved or viable embryos using conventional IVF. Whereas high gonadotropin stimulation cannot compensate for the significantly reduced number of ovarian follicles another suggested strategy in POR was to exploit the multiple follicular waves within the ovarian cycle by a double stimulation protocol follicular and luteal in the same ovarian cycle. Whether this approach yields better results to two cycles of conventional COH is.

Dual Stimulation or double stimulation is done in patients who show a poor response to hormonal injections usually due to a poor ovarian reserve. Poor response usually corresponds to retrieval of fewer mature eggs. As the name suggests dual stimulation has 2 rounds of stimulation done in order to retrieve as many mature eggs as possible.