Calcium sulfate bone graft substitute

It is a reasonable alternative to autogenous bone graft for benign bone lesions. Calcium sulfate plaster of Paris has a long clinical history for use as a bone graft substitute in various skeletal sites.

The current authors examined the in vivo response of calcium sulfate pellets alone or in combination with autogenous bone graft in a bilateral critical-size distal femoral cancellous defect in an adult sheep model.

Calcium sulfate bone graft substitute. Calcium sulfate has been used as a bone graft substitute in many fields from dentistry to orthopedics. However the results of many studies have yielded inconclusive results. In the present study a sheep model was used with tibial and femoral metaphyseal defects to determine whether calcium sulfate.

Calcium Sulfate as Bone Graft Substitute in the Treatment of Osseous Bone Defects A Prospective Study Abstract. Calcium sulfate belongs to synthetic ceramic group of bone graft substitutes having an. Treatment of large osseous bone defects is challenging.

Calcium sulfate is a well-tolerated biodegradable osteoconductive bone graft substitute. It is a reasonable alternative to autogenous bone graft for benign bone lesions. Calcium sulfate plaster of Paris has a long clinical history for use as a bone graft substitute in various skeletal sites.

The current authors examined the in vivo response of calcium sulfate pellets alone or in combination with autogenous bone graft in a bilateral critical-size distal femoral cancellous defect in an adult sheep model. The use of calcium sulfate mixed with autologous iliac crest bone marrow aspirate as a bone graft substitute in the rabbit posterolateral spinal fusion model failed to produce fusion. When direct current electrical stimulation was added a trend toward successful fusion was observed in a dose-dependent manner but no statistical significance could be demonstrated.

Other bone graft substitutes such as coralline hydroxyapatite. Calcium sulfate plaster of Paris has been used since 1892 to fill bone defects and to act as a bone graft substitute. Calcium sulfate is an inorganic osteoconductive substance.

Calcium sulfate has been used as a bone graft substitute in many fields from dentistry to orthopedics. However the results of many studies have yielded inconclusive results. In the present study a sheep model was used with tibial and femoral metaphyseal defects to determine whether calcium sulfate was as effective as autograft and allograft in promoting new bone formation in a critical size.

Calcium sulfate was found in these studies to be generally well tolerated by tissues and resorbed. These encouraging but sometimes inconsistent results sparked additional investigation on the use of calcium sulfate as a bone graft substitute containing antibiotics to treat infected bone. The fracture zone is immobilized by its setting reaction initiated by its wetting and subsequent conversion to a strong.

Historically plaster of Paris POP or calcium sulfate has been used in pellet dihydrate form as a bone graft substitute. The setting properties of calcium sulfate can allow this material to be used as a slurry which has advantages of ease of handling and delivery via injection. The form of POP may have.

Bone Graft Substitutes Resorption rates vary widely Dependant on composition Calcium sulfate -very rapid Hydroxyapatite HA very very slow Some products may be combined to optimize resorption rate Also dependant on porosity geometry. During the past 30 years a variety of synthetic bone graft substitutes has been developed with the aim to minimize these complications. The benefits of synthetic grafts include availability sterility and reduced morbidity.

The present article examines the relevance of synthetic bone graft substitutes their mechanical properties and clinical application. Abstract Calcium sulfate has been used as a bone graft substitute in many fields from dentistry to orthopedics. However the results of many studies have yielded inconclusive results.

Calcium sulfate CS features a unique position among all regenerative bone graft substitutes. With more than 100 years of documented clinical success Dreesmann 1892 Thomas and Puleo 2008 it has a longer history of clinical use when compared to most currently available biomaterials. Synthetic bone substitutes consist of hydroxyapatite tricalcium phosphate calcium sulfate or a combination of these minerals.

Synthetic porous substitutes share several advantages over allografts including unlimited supply easy sterilization and storage. However they also have some disadvantages such as brittle properties variable rates of resorption and poor performance in some. Calcium sulfate plaster of Paris has a long clinical history for use as a bone graft substitute in various skeletal sites including mandibular 1689223036 craniofacial 111318203132 distal radius 21 long bone defects 51017272837 spinal fusions 16 osteochondral defects 25 and benign bone lesions.

With the exception of calcium sulfate these mineral substitutes are physiologic calcium salts. HA deposits on a matrix of type I collagen where cellular activity occurs to create the underlying latticework of mammalian bone. The mineral backbone.

Autograft bone has osteogenic potential because surviving bone cells and matrix proteins are present. Calcium phosphate bone graft substitutes are usually either tricalcium phosphate or hydroxyapatite which is the primary mineral in bone. One example of a commercially available hydroxyapatite-based bone graft substitute is Pro-Osteonfrom BiometOsteobiologics.

Among calcium sulfate-based bioceramics the a-Calcium sulfate hemihydrate CSH powder CaSO 4 ½ H 2 O is very popular as bone substitute in clinical fields6. Furthermore calcium sulfate substitutes occupy a unique position in the group of regenerative materials and are recognized as safe and bioactive implant materials. They have been successfully used in bone substitution although.