Alpha amylase inhibitor diabetes

α-Amylase Inhibitors α-Amylase inhibitors inhibit the activity of salivary and pancreatic amylase in vitro and in vivo. The α-amylase inhibitors act as an ant nutrient that control rate of digestion and absorption of carbohydrates.

Medicinal plants as inhibitors of α-amylase and α-glucosidase has been reviewed by several authors.

Alpha amylase inhibitor diabetes. Extracts of six selected Malaysian plants with a reputation of usefulness in treating diabetes were examined for alpha-amylase inhibition using an in vitro model. Inhibitory activity studied by two different protocols with and without pre-incubation showed that Phyllanthus amarus hexane extract had alpha-amylase inhibitory properties. Hexane and dichloromethane extracts of Anacardium occidentale.

The inhibition of alpha-glucosidase and alpha-amylase enzymes involved in the digestion of carbohydrates can significantly reduce the post-prandial increase of blood glucose and therefore can be an important strategy in the management of blood glucose level in type 2 diabetic and borderline patients. Currently there is renewed interest in plant-based medicines and functional foods. Diabetes mellitus is the most widespread disorders prevalent in current period.

α-Amylase enzyme plays a key role in the onset of the abnormal condition by breaking starch into glucose. Hence its inhibitors need to be studied thoroughly. Due to the various side effects posed by the existing commercial non-proteinaceous inhibitors exploration of the natural plant-based inhibitors of the.

Basically alpha-amylase inhibitors are classified into two groups. Proteinaceous inhibitors and non-proteinaceous inhibitors. Recently non-proteinaceous inhibitors are being explored which includes chalcones flavones benzothiazoles etc.

As the potential antidiabetic agents. By α-amylase inhibition in diabetics lowering blood sugar levels can cause to weight reduction in obese individuals. The studies on α-amylase inhibitors have been done on the broad range of research.

In a research for reducing of the amount of digestible carbohydrates and low blood sugar the idea has been to use carbohydrates with low GI. Alpha-amylase Karthic et al2008. Andrographis lineata Shade dried leaf powder taken orally along with cows milk or goats milk has been used traditionally to treat diabetes however there is no proper scientific evidence to support its hypoglycemic activity.

Further investigation may result in the development of good. In this study the alcoholic extract of flower and leaf of Catharanthus roseus was tested for its α-amylase and α-glucosidase inhibitory activity to understand its anti-diabetic potentialVarying. Similarly α- amylase is an enzyme that is secreted by the pancreas and salivary glands that can hydrolyze starches and oligosaccharide into simple sugars.

Inhibition of these enzymes can retard carbohydrate digestion thus causing a reduction in the rate of glucose absorption into the blood. The alpha amylase inhibitor prevents starch digestion by completely blocking access to the active site of the alpha-amylase enzyme. Factors that affect the activity of the alpha-AI isoform inhibitor are pH temperature incubation time and the presence of particular ions.

The optimum pH for the inhibitor is 45 to 55 and the optimal temperature is 22 to 37C. There is no activity at 0C and the inhibitor is. Alpha-glucosidase inhibitor two drugs such as acarbose Precose and Miglitol Glyset11 have been used in clinic.

Acarbose a well-known and efficacious alpha-amylase and alpha-glucosidase inhibitor is a post-prandial acting anti-diabetic drug. Medicinal plants as inhibitors of α-amylase and α-glucosidase has been reviewed by several authors. A variety of plants has been reported to show an enzymatic inhibitory activity and so many are relevant to the treatment of type 2 diabetes Benalla 2010.

Published research suggests that there is a direct. A purified pancreatic alpha-amylase inhibitor alpha-AI from white beans Phaseolus vulgaris was administered orally 100 mgkg body weight dissolved in 9 g NaCll for 22 d to non-diabetic ND and type 2 diabetic neonatal diabetes models n0-STZ and n5-STZ male Wistar rats. Three most common anti-diabetic drugs that act mainly by inhibiting carbohydrate digestion and absorption are- Acarbose BAY g 5421 - This inhibitor is of microbial origin and it was the first alpha-glucosidase inhibitor commercially available for diabetes treatment which inhibits the activities of alpha-amylase33-39 sucrase and maltase.

The α-amylase inhibitors act as an ant nutrient that control rate of digestion and absorption of carbohydrates. Also potentially become useful in control of obesity and diabetes. α-Amylase Inhibitors α-Amylase inhibitors inhibit the activity of salivary and pancreatic amylase in vitro and in vivo.

They can impair the growth and metabolism of animals when given at high levels in the diet but may have beneficial uses in treatment of obesity or diabetes. Thus the inhibitors of both α-amylase which breaks down long-chain carbohydrates and α-glucosidase which catalyses the cleavage of glucose from disaccharide are effective in delaying glucose absorption. The inhibition of α-amylase activity together with α-glucosidase is considered to be an effective strategy for the control of diabetes.

From this point of view more researchers have focused on the search for more effective inhibitors of anti-diabetic.